Preheat the oven to 375°F (190°C) and grease a 9x13-inch baking dish.

Bring a large pot of salted water to a boil. Cook the macaroni 1–2 minutes short of package al dente time. Drain and set aside.

Whisk the cornstarch into 1 cup of cold whole milk until fully dissolved with no lumps.

In a medium saucepan over medium heat, melt the butter, then add the remaining 3 cups of milk and the evaporated milk. Once warm, whisk in the cornstarch slurry.

Cook, whisking constantly, for 3–4 minutes, until the sauce thickens and coats the back of a spoon.

Remove the saucepan from the heat. Stir in the mustard powder, garlic powder, paprika, salt, and pepper.

Add 2 cups of the cheddar and all of the Monterey Jack, a handful at a time, stirring until fully melted and smooth.

Add the drained pasta to the sauce and stir until evenly coated.

Pour the mixture into the prepared baking dish and spread into an even layer. Top with the remaining 1 cup of cheddar.

In a small bowl, toss the panko with the Parmesan and melted butter, then scatter evenly over the top.

Bake uncovered for 20–25 minutes, until golden on top and bubbling at the edges.

Let rest 5 minutes before serving.